Last site update August 2023. My name is Fabio Barteri and I am a Computational Biologist at the Barcelona Beta Brain Research Centre and Universitat Pompeu Fabra. I work as a Bioinformatics Lab Manager in the group led by Prof. Arcadi Navarro.

Research interests

My scientific activity revolves aroud the implementation of computational approaches to infer genome-phenome maps from evolutionary data.

Convergent Amino Acid Substitutions

Amino Acid substitutions that are consistent with phenotype convergence can indicate that the protein is linked to that phenotype. We call these mutations Convergent Amino Acid Substitutions (CAAS). CAAS can represent an important starting point to reconstruct the genetic background of complex traits. At the moment, we are striving to improve our CAAS detection and validation strategy.

CAAStools, a toolbox to identify and test Convergent Amino Acid Substitutions

In the last years, our lab @ UPF-Barcelona has developed a strategy to identiy, test and validate CAAS in orthologous protein alignments from different mammalian species. In 2023 we released CAAStools, a toolbox written in Python that allows the user to detect and test CAAS.

CAAStools source code is available in GitHub. Introductory pre-print is on BioRXiv.

INSTALLATION

git clone https://github.com/linudz/caastools
export PATH=$PATH:caastools_folder_path

Simulation of trait evolution.

Quantitative traits can variate considerably within and between species. Sometimes this variation comes from neutral evolution, sometimes is the consequence of selective pressure.

Lab Management

As a Bioinformatics lab manager in the Navarro’s group, I take care of several aspects of the bioinformatics routine in the lab, from the HPC accounts to the pipeline creation supervision and bioinformatics training of lab interns.

Selected Publications

A full list of my publications is available in my Google Scholar. Here I report just a few references that better explain what I am doing at the moment.

CAAStools, a toolbox to identify and test Convergent Amino Acid Substitutions. Barteri et al., BiorXIV, 2023

Comparative analysis of mammal genomes unveils key genomic variability for human life span. Farré et al., Molecular Biology and Evolution, 2021

The Role of Transposable Elements in Congenital Malformations with Notes on Their Potential Implications for Morphological Evolution in Mammals. Barteri and Esteve-Altava, Current Molecular Biology Reports, 2023

A few more facts about me

I come from Rome where I was born and raised. I moved to Barcelona in 2015 for my PhD, and I have been living there ever since.

The nickname linudz comes from “Linus” and it is a reference to Linus Van Pelt. It has always been my nickname on the internet (even though there are few other “linudz” out there).

I have graduated in Cell Biology with a computational thesis on Gut Microbiota. Then I did my PhD in Evolutionary Plant Genomics to later move to animal evolution.

I was on Mastodon before it became muskstream. I have merged my old scientific account and personal account in a znew account on ecoevo. You’ll find me there, even though I still have my Twitter/X Account active.

I have always been an antifascist activist. I participated in several grassroot organizations (mostly anarco-socialist), both in Rome and in Barcelona.

I support AS Roma, but I use to go to Barcelona’s local team CE Europa games on Sunday. This latter is probably the third most hipster thing I do (after being on Mastodon and having this website).